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05/30/26

Cancer diagnostic delay rates associated with a population-based screening trial evaluating a cell-free DNA multicancer early detection test.

Mann, Sean; Nascimento de Lima, Pedro; Eagan, Joshua; Ulyte, Agne; Griffin, Beth Ann. JAMA

Collection Topics
Big Three Conditions Epidemiology Equity, Access, and Timeliness Tests, Screening, and Laboratory Processes
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Summary

Novel innovations in cancer diagnostic care at a population level may have unintended "spillover" side effects. This study compared cancer diagnostic delays across NHS regions participating in the large multicancer Galleri screening trial with those that were not. Participating regions experienced a small but statistically significant increase in diagnostic delays during the trial’s first six months in part possibly due to increased cancer referral patterns, highlighting the importance of evaluating system-level consequences alongside potential benefits of new screening technologies.

Read the paper
Mann S, Nascimento de Lima P, et al. Cancer diagnostic delay rates associated with a population-based screening trial evaluating a cell-free DNA multicancer early detection test. JAMA. 2026;336(2):125-134.