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08/26/26

Clinical urgency of incidental findings in the first year of the 4-IN-THE-LUNG-RUN lung cancer screening program.

Walstra, Anna N H; Heuvelmans, Marjolein A; Han, Daiwei; Hubert, Juul; van den Bosch, Isabelle; Schmitz, Alexander M Th; Oudkerk, Sytse F; van Leeuwen, Maarten; Nair, Arjun; Silva, Mario; Gratama, Jan Willem C; van der Aalst, Carlijn M; de Koning, Harry J; Oudkerk, Matthijs. Eur J Cancer.

Collection Topics
Equity, Access, and Timeliness Tests, Screening, and Laboratory Processes
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Summary

Screening can uncover abnormalities that create diagnostic work without necessarily improving health. This Dutch prospective multicenter study examined incidents and outcomes of incidental findings among 4,122 participants undergoing low-dose CT. Radiologists reported findings in 7.1%, but centralized expert review reduced those requiring primary-care follow-up to 1.8%, and only 0.5% were referred. The results surface opportunities to embed improvement tactics into lung cancer screening programs to limit unnecessary diagnostic cascades.
Read the paper
Walstra ANH, Heuvelmans MA, Han D, et al. Clinical urgency of incidental findings in the first year of the 4-IN-THE-LUNG-RUN lung cancer screening program. Eur J Cancer. 2026;244:116909.