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12/01/25

Diagnostic accuracy of severe acute respiratory infection definitions in hospitalized children: a systematic review and meta-analysis.

Hersi, Leo; Kant, Tuana; Kaziev, Caitlyn L; Farrar, Daniel S; Bryan, Noah; Cunningham, Jessie; Mtaweh, Haifa; Mahant, Sanjay; Morris, Shaun K; Gill, Peter J. JAMA Netw Open.

Collection Topics
Big Three Conditions Measurement, Monitoring, and Event Analysis
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Summary

Inconsistent measurement hampers disease detection, surveillance, and public health readiness. This evidence analysis of 13 studies finds that the World Health Organization (WHO) 2014 severe acute respiratory infection (SARI) case definitions have lower sensitivity but higher specificity in children of younger ages, indicating SARI-based diagnostic accuracy may underestimate pediatric disease burden particularly for infants.

Read the paper
Hersi L, Kant T, Kaziev CL, et al. Diagnostic accuracy of severe acute respiratory infection definitions in hospitalized children: a systematic review and meta-analysis. JAMA Netw Open. 2025;8(12):e2550298.