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02/20/26

Diagnostic outcomes among patients with positive multi-cancer early detection test results.

O'Donnell, Elizabeth K; Kauffman, Tia L; Asnis, Sydney; Kelly, Victoria A; Matthews, Ella; Kartsounis, Matheos; Dharaneeswaran, Harita; Beckwith, Jenna B; Bennett, Ciola; Marto, Marjorie; Parmigiani, Giovanni; Rebbeck, Timothy R; Ghobrial, Irene M; Syngal, Sapna; Marinac, Catherine R. Cancer Res Commun.

Collection Topics
Big Three Conditions Equity, Access, and Timeliness Tests, Screening, and Laboratory Processes
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Summary

A collective approach to early disease detection may transform cancer care. This study evaluated a new blood test for early detection of multiple cancers. In a small patient group, the multi-cancer early detection (MCED) test accurately identified the cancer’s origin in about 90% of cases. MCED tests offer potential for wider screening and early diagnosis but face challenges like specialist access, false positives, and follow-up issues.

Read the paper
O’Donnell EK, Kauffman TL, Asnis S, et al. Diagnostic outcomes among patients with positive multi-cancer early detection test results. Cancer Res Commun. 2026;6(3):511-515.