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01/28/26

Diagnostic tests for ovarian cancer in premenopausal women with non-specific symptoms (ROCkeTS): prospective, multicentre, cohort study.

Sundar, Sudha; Agarwal, Ridhi; Scandrett, Katie; Davenport, Clare; Van Calster, Ben; Johnson, Susanne; Sengupta, Partha; Selvi-Vikram, Radhika; Kwong, Fong Lien; Mallett, Sue; Rick, Caroline; Kehoe, Sean; Timmerman, Dirk; Bourne, Tom; Stobart, Hilary; Neal, Richard D; Menon, Usha; Gentry-Maharaj, Aleksandra; Sturdy, Lauren; Ottridge, Ryan; Deeks, Jonathan J; ROCkeTS collaborators. BMJ.

Collection Topics
Big Three Conditions Tests, Screening, and Laboratory Processes
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Summary

Missing ovarian cancer can seriously harm patients. In this UK study of premenopausal women with symptoms or abnormal tests, researchers compared several ways to estimate cancer risk. The commonly used method missed many cancers. The IOTA ADNEX model found far more cases, though with more false alarms, and was recommended for practice.

Read the paper
Sundar S, Agarwal R, Scandrett K, et al. Diagnostic tests for ovarian cancer in premenopausal women with non-specific symptoms (ROCkeTS): prospective, multicentre, cohort study. BMJ. 2026;392:e083912.