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01/28/26

Evaluating the impact of age on prostate cancer overdiagnosis using long-term follow-up from a randomised trial.

Brentnall, Adam R; Rebolj, Matejka; Sasieni, Peter; Funston, Garth; Gabe, Rhian; Vickers, Andrew. medRxiv.

Collection Topics
Big Three Conditions Overdiagnosis Epidemiology
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Summary

Prostate cancer overdiagnosis significantly affects quality of life and healthcare costs. This UK trial shows overdiagnosis increases with age due to competing mortality, while rates remain low for younger men. Policies with high screening rates in older men should be reconsidered to find other opportunistic testing.

Read the paper
Brentnall AR, Rebolj M, Sasieni P, et al. Evaluating the impact of age on prostate cancer overdiagnosis using long-term follow-up from a randomised trial. medRxiv. Epub 2026 Jan 28.