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08/03/26

Fecal occult blood screening outcomes adjusted for contamination bias and nonadherence.

Blom, Johannes; Nyström, Lennarth; Jonsson, Håkan. JAMA Netw Open

Collection Topics
Big Three Conditions Culture, Work System, and Implementation Measurement, Monitoring, and Event Analysis Tests, Screening, and Laboratory Processes
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Summary

A clear understanding of program effectiveness brings value to the use of screening strategies to support diagnostic timeliness. In this Swedish population-based cohort study, investigators reassess fecal occult blood test screening outcomes after accounting for implementation biases. Screening invitation was associated with a 26% reduction in colorectal cancer mortality, while participation was associated with a 43% reduction. The findings underscore the importance of rigorous causal inference when evaluating screening programs.
Read the paper
Blom J, Nyström L, Jonsson H. Fecal occult blood screening outcomes adjusted for contamination bias and nonadherence. JAMA Netw Open. 2026;9(8):e2629856.