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06/01/26

Mailed outreach for colorectal cancer screening in community health centers: the CARES pragmatic cluster randomized clinical trial.

May, Folasade P; Brodney, Suzanne; Tuan, Jessica J; Syngal, Sapna; Chan, Andrew T; Glenn, Beth; Johnson, Gina; Chang, Yuchiao; Drew, David A; Moy, Beverly; Rodriguez, Nicolette J; Warner, Erica T; Anyane-Yeboa, Adjoa; Ukaegbu, Chinedu; Davis, Anjelica Q; Schoolcraft, Kimberly; Regan, Susan; Le Beaux, Kelley; Lee, Ellen T; Bhat, Roopa; Gordon, Alexis; Phan, Linh K; Chirino, Andrea Fernanda Cortés; Marotta, Caylin J; Kindermann, Rachel G Z; Haas, Jennifer S. JAMA Internal Med.

Collection Topics
Big Three Conditions Communication Patients and Families as Partners Tests, Screening, and Laboratory Processes Equity, Access, and Timeliness
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Summary

Colorectal cancer is the second deadliest cancer in the US and hits underresourced communities hardest. This trial compared two mail-based outreach approaches to boost screening in community health centers, including among English- and Spanish-speaking patients. At 90 days, overall screening participation was low, but the more advanced test including phone, text, and email reminders had greater participation than the test with only text reminders. Follow-up colonoscopy rates were poor. The findings demonstrate that test choice and outreach strategies must fit local context to support successful screening.
Read the paper
May FP, Brodney S, Tuan JJ, et al. Mailed outreach for colorectal cancer screening in community health centers: the CARES pragmatic cluster randomized clinical trial. JAMA Intern Med. 2026;186(6):703-712.