Patient, community, and clinician beliefs about multi-cancer detection tests: implications for the evidence needed to recommend routine use.

Multi-cancer detection tests (MCDs) may help reduce cancer deaths by enabling early diagnosis. This focus group study finds that participants valued early detection and screening convenience with a single blood test but were concerned about limited clinical validation and risks from false positives, overdiagnosis, and overtreatment. Of importance, the implementation of MCD testing at the NHS identifed safety and feasibility issues, showing the importance of more large-scale trials and clinical validation for any future implementation.