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03/20/26

Potential missed diagnostic opportunities after low dose CT screening for lung cancer: results from the National Lung Cancer Screening Trial.

Hassoon, Ahmed; Hussain, Sarah; Galiatsatos, Panagis; Lehmann, Harold; McDonald, Kathryn; Berg, Christine; Brawley, Otis. Diagnosis (Berl).

Collection Topics
Big Three Conditions Epidemiology Tests, Screening, and Laboratory Processes
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Summary

Low dose CT (LDCT) is an important screening method, but many lung cancer patients face diagnostic uncertainty after a positive initial screen. This UK study investigates potential missed diagnostic opportunities (PMDO), defined as no lung cancer diagnosis following a positive LDCT, later followed by another positive annual LDCT that confirms the disease. Over 37% of patients diagnosed with lung cancer and considered at risk for PMDO experienced at least one PMDO, highlighting an important area of focus for timely lung CA diagnosis.

Read the paper
Hassoon A, Hussain S, Galiatsatos P, et al. Potential missed diagnostic opportunities after low dose CT screening for lung cancer: results from the National Lung Cancer Screening Trial. Diagnosis (Berl). 2026;13(3):430-438.