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04/01/26

Risk stratified breast cancer screening: early outcomes and psychological impact from PRSONAL - a randomized clinical trial.

Pedersen, Line Hjøllund; Bigaard, Janne; Vejborg, Ilse; Kamstrup, Pia R; Andersen, Berit; Yang, Xin; Ficorella, Lorenzo; Dennis, Joe; Antoniou, Antonis C; Flyger, Henrik; Bojesen, Stig Egil. Breast.

Collection Topics
Big Three Conditions Overdiagnosis Teamwork
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Summary

Risk-stratified cancer screening can reduce overdiagnosis in low-risk women, improve early detection in high-risk groups, and lower costs, though implementation is difficult. This trial shows that automated risk-based screening is feasible and acceptable with minimal impact on short-term psychological well-being, but these early results should be viewed cautiously since the main outcome will be measured after an additional 17 months of follow-up.

Read the paper
Pedersen LH, Bigaard J, Vejborg I, et al. Risk stratified breast cancer screening: early outcomes and psychological impact from PRSONAL - a randomized clinical trial. Breast. 2026;86:104743.