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03/01/26

Screening for lung cancer: a systematic review of overdiagnosis and its implications.

Fernández-Sáenz, Fiorella Karina; de la Torre-Perez, Laura; Baldwin, David R; van der Aalst, Carlijn; Thorat, Mangesh; Ritchie, David; Carvalho, Andre L; Espina, Carolina; Solà, Ivan; Canelo-Aybar, Carlos; Pissinis, Moira Magdalena; Alonso-Coello, Pablo; Pinto, Ana Carolina Pereira Nunes. Mol Oncol.

Collection Topics
Big Three Conditions Overdiagnosis Tests, Screening, and Laboratory Processes
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Summary

Overdiagnosis refers to the detection of conditions through screening that would not have caused symptoms or affected patient health. This review examines the extent, harms, and economic impact of lung cancer overdiagnosis from low-dose CT (LDCT) screening in high-risk groups, finding that LDCT marginally raises overdiagnosis and societal costs.

Read the paper
Fernández-Sáenz FK, de la Torre-Perez L, Baldwin DR, et al. Screening for lung cancer: a systematic review of overdiagnosis and its implications. Mol Oncol. 2026;20(3):611-628.