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02/02/26

Trends in the hidden burden of cancer in an autopsy-based study over 66 years in Japan.

Uozaki, Hiroshi; Kikuchi, Yoshinao; Watanabe, Masato; Tsuchiya, Maiko; Yasui, Mariko; Watabe, Shiori; Kato, Masahiro. JAMA Netw Open.

Collection Topics
Big Three Conditions Epidemiology
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Summary

Autopsy-based studies help estimate cancer prevalence, including hidden and missed cases. This cohort study in Japan reveals a significant number of undiagnosed cancers, some with metastatic risk, emphasizing the importance of autopsies for cancer assessment and the need to improve early detection while limiting overdiagnosis.

Read the paper
Uozaki H, Kikuchi Y, Watanabe M, et al. Trends in the hidden burden of cancer in an autopsy-based study over 66 years in Japan. JAMA Netw Open. 2026;9(2):e2557812.