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08/31/26

Trends in lung cancer incidence and mortality and the potential for overdiagnosis associated with computed tomography screening across 21 countries on six continents.

Fu, Xiaoyu; Xie, Dongchen; Cui, Zixuan; Xu, Qiaoyi; Xing, Xufei; Yan, Ziqi; Liu, Zhenqiu; Chen, Xingdong; Xu, Wanghong; Suo, Chen. J Thorac Dis.

Collection Topics
Big Three Conditions Epidemiology Overdiagnosis Tests, Screening, and Laboratory Processes
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Summary

Earlier cancer detection can reduce mortality while also creating opportunities for overdiagnosis. This population-level ecological analysis used Global Burden of Disease 2021 data from 21 countries across six continents to examine lung cancer incidence and mortality trends and compared observed versus expected cases. Most countries showed parallel trends, but China showed a potential overdiagnosis signal among older women. Though the work is not a definitive finding of overdiagnosis, their findings do support careful risk-stratification of CT screening.
Read the paper
Fu X, Xie D, Cui Z, et al. Trends in lung cancer incidence and mortality and the potential for overdiagnosis associated with computed tomography screening across 21 countries on six continents. J Thorac Dis. 2026;18(8):855.