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10/22/26

Christina Applegate's experience highlights challenges of MS.

Brangham W. PBS News Hour.

Collection Topics
Cognition and Decision Making
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Summary

Multiple sclerosis (MS) can be difficult to diagnose due to heterogeneous symptoms and lack of any single definitive MRI finding or blood test. In this news interview, a neurologist discussed actor Christina Applegate’s reported MS misdiagnosis and its emotional consequences. The segment underscores the impact of diagnostic uncertainty, need for reassessment when findings are atypical, and value of second opinions to support diagnostic excellence.
Read the paper
Brangham W. Christina Applegate's experience highlights challenges of MS. PBS News Hour. October 22, 2026.