Summary
Diagnostic errors often arise not from unusual presentations but from premature acceptance of a plausible diagnosis. This retrospective study of 306 Japanese diagnostic-error cases assessed "typical" versus unusual or "chameleon" clinical presentations. Although 84.3% displayed features of the incorrect diagnosis, 64.0% also contained unusual or contradictory clues. The findings support diagnostic-safety strategies that emphasize disconfirming evidence and systematic reconsideration of initial diagnoses.
Harada Y, Kunitomo K, Amano M, et al. Presentation patterns for initial incorrect diagnosis in diagnostic errors. Diagnosis (Berl). Epub 2026 Oct 2